The prevalence of human papillomavirus infection in Mombasa, Kenya
Auteurs & affiliatie
Hugo De Vuyst, Maria Rita Parisi, Andrew Karani, Kishor Mandaliya, Lucy Muchiri, Salvatore Vaccarella, Marleen Temmerman, Silvia Franceschi, Flavia Lillo
Abstract
Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services. Results Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9-46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4-45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for >= 3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.
Publicatiedatum:
2010
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The_prevalence_of_human_papillomavirus_infection_in_Mombasa__Kenya..pdf (restricted)Gerelateerde publicaties
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