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A high concentration of interferon-alpha (IFN-alpha) (>5 U/ml) in cord blood was used as the criterion for establishing our study group, In a collection from deliveries by 269 Kenyan women, 16 such cord samples with matching maternal blood and placental biopsies were identified, These 16 were studied in detail together with 23 randomly selected among those with low cord IFN-alpha levels, The levels of IFN- in retal blood correlated with levels in their mothers for both IFN-alpha and beta but not for IFN-gamma, IFN-alpha was furthermore demonstrated in villous and decidual trophoblast fro

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A high concentration of interferon-alpha (IFN-alpha) (>5 U/ml) in cord blood was used as the criterion for establishing our study group, In a collection from deliveries by 269 Kenyan women, 16 such cord samples with matching maternal blood and placental biopsies were identified, These 16 were studied in detail together with 23 randomly selected among those with low cord IFN-alpha levels, The levels of IFN- in retal blood correlated with levels in their mothers for both IFN-alpha and beta but not for IFN-gamma, IFN-alpha was furthermore demonstrated in villous and decidual trophoblast fro

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OBJECTIVE: Our aim was to examine maternal, obstetric, and infant characteristics of mother-to-child transmission of human immunodeficiency virus-1 in Nairobi, Kenya. STUDY DESIGN: Proviral human immunodeficiency virus-1 was detected by polymerase chain reaction in peripheral blood samples taken between 6 weeks and 3 months of age from 107 children born to human immunodeficiency virus-1 seropositive women. The association of maternal, infant, and obstetric variables with human immunodeficiency virus-1 transmission was examined.

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In an attempt to minimize the problem of IUD expulsion, implantation technology has been developed and tested. The trials have extended from 1985 until the present time for interval as well as for immediate postabortal and post-placental insertion and fixation of the CuFix IUD (Gyne-Fix). The present article reports on an ongoing study with GyneFix interval insertion, with an improved inserter, in 820 women, observed up to 3 years, of whom 213 (25.9%) are nulligravid/nulliparous.

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Maternale HIV infectie heeft een negatief effect op de uitkomst van de zwangerschap: het risico op miskraam, vroeggeboorte, infectieuze complicaties en perinatale sterfte is verhoogd. De kans op perinatale transmissie bedraagt gemiddeld 30%, en wordt beduidend minder door het toedienen van zidovudine tijdens de zwangerschap. Het mechanisme en het tijdstip van transmissie van moeder naar kind zijn nog niet helemaal bekend, maar een belangrijk deel zou peripartaal plaatshebben. Het effect van zwangerschap daarentegen op de progressie naar AIDS lijkt minimaal.

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The aids epidemic is spreading rapidly in some parts of the world, including sub-Saharan Africa and Southeast-Asia, despite numerous information, education, and communication programmes. In the absence of treatment or vaccines, prevention is the only weapon in the fight against aids. Prevention implies sexual behaviour modifications and condom use. Cultural, societal, moral and socio-economic factors are important determinants of sexual behaviour, and have to be taken into account when designing effective educational programmes.

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