Publications

Three commercially available RIA kits for serum and urinary LH were assessed for their usefulness to detect endogenous LH rise in patients receiving ovarian stimulation as part of an in vitro fertilization treatment for infertility. Prerequisites included a turn-around time of 5 hours for an assay of 100 tubes. The following parameters were evaluated: reproducibility of standard curve, sensibility, precision profile, within- and between -assay precision, analytical drift, recovery and linearity.

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Infection with maternal syphilis during pregnancy is a serious condition with dramatic impact on pregnancy outcome, including perinatal wastage and congenital syphilis. Primary prevention of congenital syphilis by antenatal case-detection and treatment of infected mothers is feasible and cost-effective. Yet the implementation of syphilis prevention activities is not effective in many third world countries, due to logistic and managerial obstacles. This paper describes the achievements and the constraints of the antenatal syphilis prevention programme in Nairobi, Kenya.

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Sexually transmitted diseases (STDs) are major health problems in many parts of the world, especially in developing countries, as illustrated by high prevalence rates and a high rate of complications and sequelae. STDs are medically, socially and economically important, mainly because of their sequelae, which hit women and neonates in the first place. Ectopic pregnancy, spontaneous abortion and stillbirth, prematurity and low birth weight, congenital and perinatal infections, and puerperal maternal infections represent outcomes of pregnancy in which STDs play important aetiological roles.

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The role of gonorrhoea and other sexually transmitted diseases as risk factors for adverse pregnancy outcome defined as low birth weight, stillbirth and postpartum endometriosis, was examined in a case control study in Nairobi, Kenya. Maternal gonococcal infection was associated with very low birth weight babies (< 1500g; 17.1 versus 5.8 per cent: P<0.01; odds ratio 3.2) and with postpartum endometriosis (18.2 versus 5.6 per cent; P = < 0.001; odds ratio 4.1). The isolation rate of Neisseria gonorrhoeae increased with declining birth weight (P < 0.05).

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The role of the human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) as risk factor for spontaneous abortion was investigated in a case-control study in Nairobi, Kenya. Cases (n = 195) were women admitted with clinical signs and symptoms of spontaneous abortion, before 20 weeks of gestation. Patients with induced or clinically septic abortion were excluded. Controls were unselected pregnant women in their second or third trimester (n = 195).

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