Publications

Sexually transmitted diseases (STDs) are highly prevalent in pregnant women in many developing countries and have been associated with poor obstetric outcomes. Case detection and treatment of STDs in women is problematic and expensive, underscoring the need for other strategies. To explore the potential benefits of routine antimicrobial therapy on pregnancy outcome, we carried out a randomized, double-blind, clinical trial in one of the antenatal clinics in Nairobi, Kenya.

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Sexually transmitted diseases (STDs) are highly prevalent in pregnant women in many developing countries and have been associated with poor obstetric outcomes. Case detection and treatment of STDs in women is problematic and expensive, underscoring the need for other strategies. To explore the potential benefits of routine antimicrobial therapy on pregnancy outcome, we carried out a randomized, double-blind, clinical trial in one of the antenatal clinics in Nairobi, Kenya.

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A high concentration of interferon-alpha (IFN-alpha) (>5 U/ml) in cord blood was used as the criterion for establishing our study group, In a collection from deliveries by 269 Kenyan women, 16 such cord samples with matching maternal blood and placental biopsies were identified, These 16 were studied in detail together with 23 randomly selected among those with low cord IFN-alpha levels, The levels of IFN- in retal blood correlated with levels in their mothers for both IFN-alpha and beta but not for IFN-gamma, IFN-alpha was furthermore demonstrated in villous and decidual trophoblast fro

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A high concentration of interferon-alpha (IFN-alpha) (>5 U/ml) in cord blood was used as the criterion for establishing our study group, In a collection from deliveries by 269 Kenyan women, 16 such cord samples with matching maternal blood and placental biopsies were identified, These 16 were studied in detail together with 23 randomly selected among those with low cord IFN-alpha levels, The levels of IFN- in retal blood correlated with levels in their mothers for both IFN-alpha and beta but not for IFN-gamma, IFN-alpha was furthermore demonstrated in villous and decidual trophoblast fro

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In an attempt to minimize the problem of IUD expulsion, implantation technology has been developed and tested. The trials have extended from 1985 until the present time for interval as well as for immediate postabortal and post-placental insertion and fixation of the CuFix IUD (Gyne-Fix). The present article reports on an ongoing study with GyneFix interval insertion, with an improved inserter, in 820 women, observed up to 3 years, of whom 213 (25.9%) are nulligravid/nulliparous.

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OBJECTIVE: Our aim was to examine maternal, obstetric, and infant characteristics of mother-to-child transmission of human immunodeficiency virus-1 in Nairobi, Kenya. STUDY DESIGN: Proviral human immunodeficiency virus-1 was detected by polymerase chain reaction in peripheral blood samples taken between 6 weeks and 3 months of age from 107 children born to human immunodeficiency virus-1 seropositive women. The association of maternal, infant, and obstetric variables with human immunodeficiency virus-1 transmission was examined.

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Maternale HIV infectie heeft een negatief effect op de uitkomst van de zwangerschap: het risico op miskraam, vroeggeboorte, infectieuze complicaties en perinatale sterfte is verhoogd. De kans op perinatale transmissie bedraagt gemiddeld 30%, en wordt beduidend minder door het toedienen van zidovudine tijdens de zwangerschap. Het mechanisme en het tijdstip van transmissie van moeder naar kind zijn nog niet helemaal bekend, maar een belangrijk deel zou peripartaal plaatshebben. Het effect van zwangerschap daarentegen op de progressie naar AIDS lijkt minimaal.

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