Management of cervical dysplasia in HIV positive women

Team members: 
Hugo De Vuyst; Ingrid De Greef; Patricia Claeys; Annelies Aerssens; Stanley Luchters; Marleen Temmerman;
Team members: 
Hugo De Vuyst; Ingrid De Greef; Patricia Claeys; Annelies Aerssens; Stanley Luchters; Marleen Temmerman;

OBJECTIVES

  • To assess the effectiveness of outpatient management of precancerous lesions of the cervix in HIV positive women and to identify predictors for progression

METHODS

  • A total of 75 HIV positive women with abnormal cytology will be included in the study
  • After informed consent, a colposcopy is done, a biopsy, and genital sampling for viral tests
  • Women with a high grade dysplasia are treated with loop electrical excision procedure; women with histological confirmed CIN 1 are not treated but receive follow-up
  • Follow-up visits are planned for all women at 6 and 12 months

ACTIVTIES

  • Until now, 75 women have been included in the study
  • Of these women, 20 had a CIN1, 32 a CIN2/3 and 1 had an invasive carcinoma
  • Follow up of the cohort is ongoing

EXPECTED RESULTS

  • Distribution of HPV in HIV positve women
  • Information on HPV types and viral load in HIV positive women with precancerous lesions of the cervix, before and after treatment
  • Recurrence and progress rate after treatment of high grade lesions
  • Progression rate of low grade lesions
Undefined
Project categories: 
Geography: 
Funding agencies: 
Partners: 
Dr Othigo, Coast Provincial General Hospital Mombasa J Bogers, E Van Marck, University Antwerp Chris Verhofstede, AIDS Reference Laboratory, Ghent University
Project status: 
Ongoing
Project status: 
Closed
Period: 
1/1/2003-31/12/2007
Period: 
1/1/2003-31/12/2007
Ends on: 
Thursday, November 29, 2012
Ends on: 
Wednesday, January 1, 2003
Ends on: 
Wednesday, January 1, 2003