Kenya

The study prepares two sites (in Kigali and Mombasa) for Phase I, II and III clinical microbicide trials.

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Main objective:
•to optimize the use of ARV drugs during the antepartum, intrapartum and postpartum periods to prevent MTCT of HIV and preserve the health of the mother in settings where the majority of HIV-infected women breastfeed

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OBJECTIVES
•This study aims to describe the sexual and reproductive health of pregnant and postpartum women with HIV and investigate determinants of sexual and reproductive health in these women. Specifically, the study is designed to determine the effects of family planning counselling and contraceptive methods; length of postpartum abstinence; uptake of postpartum care; disclosure of HIV status; sexual violence; patterns of alcohol use; and infant feeding practices on the sexual and reproductive health of women in the year following childbirh.

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The overall objective of this project is to develop and apply dynamic epidemiological microsimulation models to assess the expected impact of microbicides on HIV incidence and HIV prevalence. These models will be applied in a population of female sex workers and their clients in Mombasa, Kenya. The expected impact of microbicides on HIV incidence and HIV prevalence is a function of the intrinsic efficacy of the modeled microbicide and the behavioral, demographical and epidemiological dynamics of the population in which the microbicides are introduced.

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Main objective:
•to improve the quality of the clinical laboratory

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General objective:
•To obtain a better understanding of the relation between the presence of the virus in the cervix and the vagina, and the risk of mother-child transmission of HIV.

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OBJECTIVES
•to determine the cost-benefit of HAART in mother-to-child-transmission of HIV
•to develop new methods to determine viral parameters

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General objective:
•To assess the feasibility of interventions for primary and secondary prevention interventions to improve women's reproductive health (cervical cancer screening).

Specific objective:
•To validate and enhance the specificity of visual inspection (VIA) versus PAP smear.

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OBJECTIVES
•To reduce the sexual transmission of HIV infection and STI and to decrease the complications of STI.

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