Publications

No abstract available

Undefined

The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05).

Undefined

The normal range of activities of 6 lysosomal enzymes was determined in extracts of chorionic villi samples obtained by a rigid forceps in the first trimester of pregnancy. These activities were compared to those in villi obtained after abortion and in cultured amniotic fluid cells and fibroblasts. For five of the six enzymes tested, the data suggest that first trimester prenatal diagnosis should be possible and reliable.

Undefined

Three commercially available RIA kits for serum and urinary LH were assessed for their usefulness to detect endogenous LH rise in patients receiving ovarian stimulation as part of an in vitro fertilization treatment for infertility. Prerequisites included a turn-around time of 5 hours for an assay of 100 tubes. The following parameters were evaluated: reproducibility of standard curve, sensibility, precision profile, within- and between -assay precision, analytical drift, recovery and linearity.

Undefined

Infection with maternal syphilis during pregnancy is a serious condition with dramatic impact on pregnancy outcome, including perinatal wastage and congenital syphilis. Primary prevention of congenital syphilis by antenatal case-detection and treatment of infected mothers is feasible and cost-effective. Yet the implementation of syphilis prevention activities is not effective in many third world countries, due to logistic and managerial obstacles. This paper describes the achievements and the constraints of the antenatal syphilis prevention programme in Nairobi, Kenya.

Undefined

Pages