Publications

The normal range of activities of 6 lysosomal enzymes was determined in extracts of chorionic villi samples obtained by a rigid forceps in the first trimester of pregnancy. These activities were compared to those in villi obtained after abortion and in cultured amniotic fluid cells and fibroblasts. For five of the six enzymes tested, the data suggest that first trimester prenatal diagnosis should be possible and reliable.

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The normal range of activities of 6 lysosomal enzymes was determined in extracts of chorionic villi samples obtained by a rigid forceps in the first trimester of pregnancy. These activities were compared to those in villi obtained after abortion and in cultured amniotic fluid cells and fibroblasts. For five of the six enzymes tested, the data suggest that first trimester prenatal diagnosis should be possible and reliable.

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Three commercially available RIA kits for serum and urinary LH were assessed for their usefulness to detect endogenous LH rise in patients receiving ovarian stimulation as part of an in vitro fertilization treatment for infertility. Prerequisites included a turn-around time of 5 hours for an assay of 100 tubes. The following parameters were evaluated: reproducibility of standard curve, sensibility, precision profile, within- and between -assay precision, analytical drift, recovery and linearity.

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Infection with maternal syphilis during pregnancy is a serious condition with dramatic impact on pregnancy outcome, including perinatal wastage and congenital syphilis. Primary prevention of congenital syphilis by antenatal case-detection and treatment of infected mothers is feasible and cost-effective. Yet the implementation of syphilis prevention activities is not effective in many third world countries, due to logistic and managerial obstacles. This paper describes the achievements and the constraints of the antenatal syphilis prevention programme in Nairobi, Kenya.

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Sexually transmitted diseases (STDs) are major health problems in many parts of the world, especially in developing countries, as illustrated by high prevalence rates and a high rate of complications and sequelae. STDs are medically, socially and economically important, mainly because of their sequelae, which hit women and neonates in the first place. Ectopic pregnancy, spontaneous abortion and stillbirth, prematurity and low birth weight, congenital and perinatal infections, and puerperal maternal infections represent outcomes of pregnancy in which STDs play important aetiological roles.

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