Publications

Naast AIDS komt in Oostafrikaanse landen als Kenya, Tanzania en Oeganda ook syfilis steeds meer voor. De incidentie van zowel gonorroe als Chlamydia-infecties blijft echter stabiel. Dat zegt de Belgische gynaecologe dr M. Temmerman, verbonden aan het Unversitair Ziekenhuis Gent. Vijf jaar lang heeft zij in de Keniaanse hoofdstad Nairobi onderzoek gedaan naar de gevolgen van geslachtsziekten, met name HIV-infecties, op de uitkomst van zwangerschap. Eind vorig jaar promoveerde zij op het proefschrift `HIV and pregnancy'.

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To improve the tolerance of IUDs, an implantation technique for fixation of a frameless copper IUD (CuFix Implant System: GyneFix) has been developed and tested since 1985. In the early stages of the clinical development of the GyneFix it was already apparent that the device was well tolerated, even by small nulligravid uterine cavities. The good tolerance was ascribed to the specific configuration of the device: its frameless and completely flexible form. The present long-term study confirms the validity of this innovation concept.

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Er is een dringende nood aan duidelijke richtlijnen betreffende methodologie van afname en lezing van het uitstrijkje, classificatie van de letsels, frequentie van afname, kwaliteitscontrole en beleid bij afwijkende resultaten. Humaan papilloma virus speelt een etiologische rol en wordt seksueel overgedragen. Promiscuteit bij de vrouw en/of haar partner(s) verhoogt het risico. Algemeen wordt er in ons land te dikwijls gescreend bij bepaalde vrouwen en niet of onvoldoende bij anderen.

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The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05).

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The normal range of activities of 6 lysosomal enzymes was determined in extracts of chorionic villi samples obtained by a rigid forceps in the first trimester of pregnancy. These activities were compared to those in villi obtained after abortion and in cultured amniotic fluid cells and fibroblasts. For five of the six enzymes tested, the data suggest that first trimester prenatal diagnosis should be possible and reliable.

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Three commercially available RIA kits for serum and urinary LH were assessed for their usefulness to detect endogenous LH rise in patients receiving ovarian stimulation as part of an in vitro fertilization treatment for infertility. Prerequisites included a turn-around time of 5 hours for an assay of 100 tubes. The following parameters were evaluated: reproducibility of standard curve, sensibility, precision profile, within- and between -assay precision, analytical drift, recovery and linearity.

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